SR 112 begins at an
intersection with
US 84/
SR 38 (
Bill Stanfill Highway) in the northern part of Cairo, in Grady County. It heads northwest and curves to the north, until it intersects
SR 262 (County Line Road) on the Grady–Mitchell county line. The road curves to the northeast to an intersection with
SR 65. The road continues to the northeast, passing the Camilla–Mitchell County Airport, just before entering
Camilla. In town, it meets
SR 97 (Bainbridge Road), and the two highways run
concurrent farther into town. At South Butler Street, SR 97 splits off to the northwest, while
SR 37 Truck begins concurrent with SR 112. The concurrent routes meet
SR 37 (Newton Road). At West Oakland Avenue they turn to the east. At the intersection with
US 19/
SR 3/
SR 300 (Georgia–Florida Parkway), SR 37 Truck turns to the south, while SR 112 continues to the east. The highway heads northeast and has an extremely brief concurrency with
SR 93 in
Lester. Shortly afterward, SR 112 crosses into Worth County. A little while after crossing into the county is
SR 133. The route continues to the northeast, until it enters
Sylvester. In town, it intersects
US 82/
SR 520 (Franklin Street). The three highways head concurrent to the east for less than . At the intersection with
SR 33, SR 112 turns to the north with SR 33 for just under . SR 112 splits off to the northeast and passes through
rural areas until it crosses into Turner County. In Ashburn, it meets
SR 32. The two routes run concurrent into the main part of town. There, they intersect
US 41/
SR 7. At this intersection, SR 32 departs to the south-southeast, while SR 112 continues to the east-northeast. It continues along it routing until it reaches an
interchange with
Interstate 75 (I-75), just before leaving town. At the east end of the interchange,
SR 107 begins concurrent with SR 112. Just over later, SR 107 departs to the northeast into
Rebecca. In Rebecca, it meets
SR 90 (Ashley Street East). The two routes head concurrent to the northwest for about . SR 90 splits off to the northwest along North Railroad Street, while SR 112 heads northeast, and then northward, on Sylvester Road. A few miles to the north, the road enters Wilcox County. After the county line, it continue to the north and curves to the northeast. Just before entering
Rochelle, it intersects
SR 233. The two routes begin a concurrency through town. In the southern part of town,
SR 215 (5th Avenue) joins the concurrency. A few blocks later, the concurrent routes meet
US 280/
SR 30 (1st Avenue). At this intersection, SR 215 departs to the west, while SR 112/SR 233 continue to the north. North of town, the two routes split, with SR 112 heading northwest. It travels through
Pineview and into Pulaski County. The road heads northwest and curves to the northeast to an intersection with
US 129/
SR 11. The concurrent routes head northward into
Hawkinsville. In town, they meet
SR 27/
SR 230/
SR 257 (Broad Street). At this intersection, US 129/SR 11 head west, while
US 129 Business/
SR 11 Business head north and
US 129 Alternate joins the concurrency. East of town, US 129 Alternate/SR 112/SR 257 head north, while SR 230 heads south and SR 27 head to the east. Almost immediately is an intersection with
US 341/
SR 26. Here, SR 26 joins the concurrency, while SR 27 departs to the east, running concurrent with
US 341. US 129 Alternate/SR 26/SR 112/SR 257 head northeast for a short distance, until SR 257 leaves the concurrency to the northeast. US 129 Alternate/SR 26/SR 112 head to the northeast and enter Bleckley County. In
Cochran, the three highways meet
US 23 Business/
SR 87 Business (South 2nd Street). At this intersection, SR 26 continues to the northeast on East Dykes Street, while US 23 Business/US 129 Alternate/SR 87 Business/SR 112 head northwest and then curve to the northeast to an intersection with
US 23/
SR 87. At this intersection, US 23 Business/SR 87 Business end. US 23/US 129 Alternate/SR 87/SR 112 head northwest, until SR 112 splits off to the northeast. It has an interchange with
I-16. Almost immediately, the road crosses the extreme southeastern corner of Twiggs County and enters
Allentown. The Twiggs–Wilkinson county line runs through the town's limits Farther into town is
US 80/
SR 19. The highway passes through rural areas of the county to an intersection with
US 441/
SR 29 in
Nicklesville. The road curves to the north, to meet
SR 57 (Irwinton Road) in
Toomsboro. Then, it curves to the northwest, to enter Baldwin County. SR 112 continues to the northwest and meets its northern terminus at an intersection with
SR 540. There are two sections of SR 112 that are part of the
National Highway System, a system of roadways important to the nation's economy, defense, and mobility. • The section concurrent with SR 32 in Ashburn • The section concurrent with US 129 Alternate between Hawkinsville and Cochran ==History==