The first cases of plague in this outbreak were detected in the capital
Valletta, The disease subsequently spread to a number of other households.
Containment measures (formerly Bishop's Island), a quarantine facility which was established in 1643 on the site where patients were isolated in the 1623 plague In the 1623 outbreak health authorities implemented strict measures which managed to successfully contain the spread of the disease. Sanitary Commissioners isolated people who had been infected and those who came in contact with them on
Bishop's Island in
Marsamxett Harbour. Houses of infected people were guarded, and restrictions were imposed on movement between Valletta and the rest of the island. Congregations were prohibited, and other containment measures included the banning of
cloaks, which were believed to facilitate contact between people. ==Impact==