The tornado spawned from the other supercell touched down in
St. Louis,
Missouri, then one of the largest and most influential cities in the country. It was one of at least 18 tornadoes to occur on that day, and it quickly became the third-deadliest as well as the then-costliest tornado in United States history. At least 137 people died as the tornado traversed the core of the downtown area, leaving a continuous, swath of destroyed homes, schools, saloons, factories, mills, churches, parks, and railroad yards in its wake. A few of the destroyed homes were all but completely swept away. Numerous trees were downed at the
Lafayette Park, and a barometer recorded a drop to 26.74
inHg (906
hPa at this location. The tornado crossed the
Mississippi River and struck the
Eads Bridge, where a wooden plank was found driven through a wrought iron plate. Uncounted others may have died on boats on the river, which would have swept their bodies downriver where they could not be recorded in the official death toll. The tornado continued into
East St. Louis, Illinois, where it was smaller but more intense, nearly reaching F5 intensity. Homes and buildings along the river were completely swept away and a quarter of the buildings there were damaged or destroyed. An additional 118 people were killed, 35 of whom were at the Vandalia railroad freight yards. By the end of the day, the confirmed death toll was 255, with some estimates above 400; more than 1,000 were injured. The tornado was later rated
F4 on the Fujita scale. Following the cyclone's destruction, members of Light Battery "A" and the First Regiment were placed on volunteer duty. Within an hour of the tornado striking, 32 members were on duty with ambulances and hospital corps to assist in rescue operations and to help victims. The mayor asked that both commands remain on patrol duty on May 30. Members of the bicycle corps of Company "G" First Regiment assisted when railway service was inaccessible. Telephone and telegraph wires were destroyed and streets were impassable. Officers were summoned to duty by bicycle couriers, as this was the only means of communication. Enough damage was done to the city that there was some speculation that St. Louis might not be able to host the
1896 Republican National Convention in June, just three weeks later, but after a massive clean-up effort, the convention went ahead as planned. ==Long-term impact==