1920–21 National Challenge Cup

On September 25, 1920, the National Challenge Cup held a drawing for the first round of the 1921 National Challenge Cup. The drawing paired eighty-five entrants, down from 99 the previous year being due to the fact the entrance fee had been raised from $5 to $10. The cup a single elimination format consisting of six rounds and a single game final. The entrants were dividing into an eastern and a western division which led to a final pitting St. Louis Scullin Steel F.C. from the west and Brooklyn Robins Dry Dock from the east. ==First round==

Eastern Division Northern Massachusetts District Byes: Maple Leaf F.C.; Gray & Davis F.C. Southern New England District Byes: Young Thornton F.C.; Potter & Johnson F.C.; Colonial F.C.; Greystone F.C.; Fairlawn Rovers Connecticut District Byes: Stamford F.C.; Ansonia F.C.; Columbia Gramophone Co. Southern New York District Byes: Clan MacDuff F.C.; Brooklyn F.C.; Robins Dry Dock F.C. New Jersey District Byes: Cedar Cliff F.C. Eastern Pennsylvania District Western Division Michigan District Byes: I.F.L. F.C.; One and All F.C.; Walkerville F.C.; Magyar A.A.F.C.; Caledonia F.C.; Roses F.C.; Ulster F.C. Ohio District Byes: Cleveland Greyhounds F.C.; White Motor Co. F.C.; Goodyear F.C. Northwestern New York District Byes: Oneida Community Co. F.C.; McNaughton Rangers F.C.; Rochester City Moose F.C.; Rochester Celtic F.C.; Camera Works F.C.; Kodak Park F.C. Western Pennsylvania District Bye: Madison F.C. Missouri District Byes: Ben Miller F.C.; St. Louis Screw F.C.; Scullin Steel F.C.; Innisfail F.C. Wisconsin District Bye: Simco F.C. Illinois District Byes: Thistles F.C.; Bricklayers F.C.; Harvey F.C.; Swedish American A.A.; Pullman F.C.; Rangers A.C.; Norwegian American A.A. ==Bracket==

Home teams listed on top of bracket (*): replay after tied match w/o: walkover/forfeit victory awarded ==Final==