Chattanooga Vanderbilt started the season with a 45–18 victory over
Chattanooga. Chattanooga did not lose another game and was champion of the
Southern Intercollegiate Athletic Association.
Ouachita In the second week of play, Ouachita was defeated 39–10.
Centre Vanderbilt overwhelmed Centre 53–6.
Texas In
Dallas, the Commodores suffered the season's only loss to
Texas Longhorns 13–6. Texas scored on a 20-yard pass from Baldwin to Ford, and on a run from Baldwin. The starting lineup was Kelly (left end), Lusky (left tackle), Cecil (left guard), V. Sharpe (center), Oliver (right guard), Abernathy (right tackle), Creson (right end), Spears (quarterback), McIlwain (left halfback), Owen (right halfback), Armistead (fullback). The starting lineup was Abernathy (left end), Hawkins (left tackle), Kelly (left guard), V. Sharpe (center), Cecil (right guard), Lusky (right tackle), Creson (right end), Spears (quarterback), Owen (left halfback), McIlwain (right halfback), Armistead (fullback).
Kentucky Kentucky was beaten 34–6. The starting lineup was James (left end), Hawkins (left tackle), Kelly (left guard), Oliver (center), Cecil (right guard), Lusky (right tackle), Creson (right end), Spears (quarterback), Owen (left halfback), McIlwain (right halfback), Armistead (fullback).
Georgia Tech A wet field and a strong defense, ranked by one researcher as best in the South, helped
Georgia Tech reassert itself and hold Vanderbilt to a scoreless tie, despite the Commodores having the upper hand in play. A strong game had been predicted, showcasing each team's backfield stars in
Stumpy Thomason of Tech and
Bill Spears of Vanderbilt.
Vernon Sharpe suffered a knee injury before the game. The starting lineup was Abernathy (left end), Hawkins (left tackle), Kelly (left guard), V. Sharpe (center), Cecil (right guard), Lusky (right tackle), Creson (right end), Spears (quarterback), Owen (left halfback), McIlwain (right halfback), Armistead (fullback)
Tennessee Robert Neyland was hired to coach Tennessee in 1926 by
Nathan Dougherty with the explicit goal to "even the score with Vanderbilt", and had his first great team in
1927. McGugin's Commodores led 7–0 until a late
Dick Dodson run tied the score. "After the game McGugin questioned each of his players as to his whereabouts during the run. Without exception the players claimed that two men had blocked them. McGugin shrugged. "Well, we'll just protest the play. It's perfectly obvious that Tennessee had twenty-two men on the field." The starting lineup was Abernathy (left end), Hawkins (left tackle), James (left guard), V. Sharpe (center), Cecil (right guard), Lusky (right tackle), Creson (right end), Spears (quarterback), Owen (left halfback), McIlwain (right halfback), Armistead (fullback).
Maryland Spears played only in the first half in the 39–20 win over Maryland, but completed 10 of 12 passes.
Sewanee Vanderbilt defeated Sewanee 26–6. The starting lineup was Abernathy (left end), Hawkins (left tackle), Oliver (left guard), V. Sharpe (center), Cecil (right guard), Lusky (right tackle), Creson (right end), Owen (quarterback), McIlwain (left halfback), Sims (right halfback), Armistead (fullback).
Alabama The Commodores faced
Wallace Wade's
Alabama Crimson Tide in the season finale. Spears gained more than the entire Alabama backfield as the Commodores won 14–7. The highlight of Vanderbilt's first scoring drive was a pass from Spears to Armistead of 20 yards, down to the 3-yard line, from which Armistead later ran it in. On Alabama's scoring drive, Red Brown ran 23 yards on a reverse, down to the 4-yard line.
Tony Holm eventually got the score. In the fourth quarter, Spears led the winning drive, once circling end for 34 yards, tackling by Starling just as he seemed to break free. He then passed to Larry Creson for 10 yards, ran for 6, and then 13 more around end to the 16-yard line. After Spears and Armistead worked it down to the 9-yard line, a pass to Roy Gibson got the touchdown. ==Postseason==