The 1980 Clemson Tigers football team was an American football team that represented Clemson University in the Atlantic Coast Conference (ACC) during the 1980 NCAA Division I-A football season. In its third season under head coach Danny Ford, the team compiled a 6–5 record, tied for fourth place in the ACC, and was outscored by a total of 222 to 217. The team won the 100th ACC game in Clemson history on November 1 and played its home games at Memorial Stadium in Clemson, South Carolina.