The 2005 UAB Blazers football team represented the University of Alabama at Birmingham (UAB) as a member of the East Division in Conference USA (C-USA) during the 2005 NCAA Division I-A football season. Led by 11th-year head coach Watson Brown, the Blazers compiled an overall record of 5–6 with a mark of 3–5 in conference play, tying for fifth place at the bottom of the standings in C-USA's East Division. The team played home games at Legion Field in Birmingham, Alabama.