The 2006 UAB Blazers football team represented the University of Alabama at Birmingham (UAB) as a member of the East Division in Conference USA (C-USA) during the 2006 NCAA Division I FBS football season. Led by Watson Brown in his 12th and final season as head coach, the Blazers compiled an overall record of 3–9 with a mark of 2–6 in conference play, placing fifth in C-USA's East Division. The team played home games at Legion Field in Birmingham, Alabama.