The 2006 UNLV Rebels football team represented the University of Nevada, Las Vegas (UNLV) as a member of the Mountain West Conference (MW) during the 2006 NCAA Division I FBS football season. Led by second-year head coach Mike Sanford Sr., the Rebels compiled an overall record of 2–10 record with mark of 1–7 in conference play, tying for eighth place at the bottom of the MW standings. The team played home games at Sam Boyd Stadium in Whitney, Nevada.