Dayton region First round Sixth seeded '''St. John's
took on the eleventh seeded Ivy League champion Princeton'''. The Tigers had won their last 21 games, the nation's third longest win streak. While Princeton stayed close early, only down 15–12 at one time, they missed 15 of their next sixteen shots while St. John's pulled out to a sixteen-point halftime lead. The two teams played roughly evenly the second half, but the halftime lead was more than enough and the Red Storm prevailed 65–47. Fourteenth seeded
Louisiana Tech (La Tech) was returning to the NCAA Tournament after a three-year absence. Under
Maggie Dixon award winning new coach
Teresa Weatherspoon, the Lady Techsters took on third seeded
Florida State. La tech started out strong, pulling out to a nine-point lead late in the first half, but the Seminoles fought back to a 40–40 tie at halftime. The score was close well into the second half, with Florida State holding onto a one-point lead with just under nine minutes to go, but the Seminoles gradually increased the lead to ten. Although the Lady Techsters cut the lead in half to 65–61 with just under two minutes left, they would not score again and Florida State would hit ten straight free throws in the closing minutes to win 75–61.
Second round Kansas City region First round '''Michigan State's''' fifth year senior Aisha Jefferson had stomach problems from a pre-game meal severe enough to keep her hunched over the front of a trash can in the first half, but it wasn't enough to keep her out of the game. She scored 17 points along with nine rebounds to help lead the fifth seeded Spartans over 12 seed
Bowling Green 72–62. Thirteenth seeded
Liberty tried to challenge fourth seeded
Kentucky, scoring the first six points, and leading by as much as nine early, but Kentucky's freshman A'dia Mathies, scored 32 points to set a personal career high and an NCAA tournament record for Kentucky to help the Wildcats retake the lead. The Liberty Flames fought back, and had a slim two-point lead at halftime, but the Kentucky team, behind 26 of 36 free-throws, pulled ahead to win 83–77.
Second round Memphis region First round Seventh seeded
LSU easily beat tenth seeded
Hartford 60–39. This was Hartford's first at-large invitation to the NCAA Tournament, but without leading scorer Erica Beverly, lost to a season-ending injury, the Hawks were unable to stay with the Tigers. LSU held Hartford scoreless for nearly eight minutes, scoring 17 consecutive points to take an early lead they would never give up. Top seeded
Tennessee defeated 16 seed
Austin Peay 75–42. Playing at their home court "The Summitt", the Lady Vols scored 15 points before allowing a score by the Lady Govs. Second-seeded
Duke took on 15 seed
Hampton in Cameron Indoor Stadium, the Blue Devils home court, where Duke had won twelve consecutive NCAA Tournament games. The Pirates managed to hold a slim lead in the early minutes of the game, but Duke quickly took over, moving out to a 40–14 halftime lead and winning easily 72–37. Eighth seeded
Dayton took on ninth seeded
TCU in their first ever NCAA appearance. Early in the second half, it appeared that Dayton would only be playing one game, as they were behind by 18 points, 50–32. However, the Flyers did not fold, and hit a basket with one second left in the game to win by a single point 67–66. Twelve seed
Marist scored the first seven points in their game against five seed
Georgetown, which may have reminded fans of the way Marist played in 2007, coming to the tournament as a 13 seed, and knocking off Ohio State and Middle Tennessee to make it to the round of sixteen. Georgetown, which hasn't been to the tournament in 17 years, started slowly, but managed to hold a two-point lead at halftime. Georgetown's Monica McNutt hit back-to-back three-pointers to start a 13–0 run at the beginning of the second half. The Red Foxes would never close the gap, and Georgetown went on to win 62–42. Fourth seed
Baylor took on 13th seed
Fresno State. Baylor's
Brittney Griner returned to the floor, after sitting out a two-game suspension for hitting an opponent in a game. This was freshman Griner's first tournament, and she confessed to having jitters, but she controlled the lane, and help keep Fresno State from winning their first ever NCAA game. Baylor held a six-point lead at halftime, which they stretched out to a 69–55 final score.
Sacramento region First round A fifteen seed has never beaten a two seed in the NCAA Women's Tournament, but with under five minutes left in the first half, 15th seeded
Portland State was ahead of the second seed
Texas A&M. The lead didn't last long, as the Aggies pulled to an eight-point lead at halftime, and extended the lead through the second half. Texas A&M's Tanisha Smith just missed a triple double, with nine assist to go along with 17 points and 10 rebounds. The final score favored the Aggies 84–53. Normally, a four seed would be a large favorite against a 13 seed, but normally, the four seed isn't required to bench one of their players, and not just any player, but
Andrea Riley, the third leading scorer in Division 1. Two years earlier, Riley had thrown punch in an NCAA game, which earned her a one-game suspension. NCAA rules required that it be an NCAA game.
Oklahoma State lost the game in which the punch was thrown, and did not make it to the Tournament in 2009, so the suspension was served two years later. The 13th seeded
Chattanooga tried to take advantage of the situation, and led by as much as 18 in the first half. Riley could only cheer on the team from the bench. Freshman Toni Young responded by scoring 22 points, and senior Tegan Cunningham, after struggling in the first half, began hitting in the second half and ended up with 25 points, enough to help Oklahoma State win 70–63. The 8/9 match-up between
Iowa and
Rutgers pitted current Rutgers coach
C. Vivian Stringer against the program she helped bring to national prominence two decades earlier. Iowa had lost a game in the Big Ten tournament, after a big lead, and they didn't want to experience that again. Rutgers played even with the Hawkeyes, in the second half, but the seven point halftime lead stood up and Iowa won 70–63. Seventh seed
Gonzaga took on tenth seeded
North Carolina. Gonzaga's Tiffanie Shives was scoreless for 31 minutes, but then scored 14 in the next five minutes. Her first basket cut the Tarheels lead to two, and her next basket gave Gonzaga a lead they would not relinquish, although North Carolina cut the lead to one with under four minutes to go, only to fall short 82–76. Twelfth seed
Tulane stayed with fifth seed
Georgia for 32 minutes, in a game with five lead changes and four ties, but then the Bulldogs went on an 18–2 run to take the lead for good. Georgia's Ashley Houts would score 22 points for the winning team, and teammate Angel Robinson had a double-double (18 points, 13 rebounds) to help lead the Bulldogs over the Green Wave 64–59. The last time Stanford was a number 1 seed, they became to only top seed in the men's or women's tournament to lose to a sixteen seed. Earlier in the day, the top seeded men's team, Kansas, lost to Northern Iowa, so no one felt safe in the opening match against UC Riverside. Stanford jumped out to an 8–0 lead, and behind Ogwumike's double-double (19 points, 11 rebounds) won easily over the Big West champion 79–47.
Second round ==Brackets==