The Sabres participated in the
2011 NHL Premiere, playing their first two regular season games in Europe. After a 2–0 start in Europe, the Sabres returned home and continued to play well. They had a record of 10–5 going into a November 12 game against the
Boston Bruins, where, in the first period,
Ryan Miller left his crease to play a puck and was hit by the Bruins'
Milan Lucic. Miller suffered a concussion and neck injury on the hit and would go on to miss nine games; his first game back he took another blow near the head area, this time via Nashville Predators player Jordin Tootoo. Lucic was penalized for charging on the play but was not suspended or fined by the League. During the middle part of the season, injuries plagued the team. By the
All-Star break the Sabres sat in 14th place in the Eastern Conference and had 225-man-games lost to injury.
Jason Pominville was the only Sabre named to the All-Star Game roster.
Luke Adam was one of 12 rookies selected to participate in the All-Star Skills Competition. During the 33 game stretch from the Bruins game (November 12) to January 24, the Sabres had a record of 9–19–5. The poor play included a team record 12-game road losing streak and a run of five consecutive regulation loses on a single road trip. Things then began to turn around with a shootout win at the
New Jersey Devils on January 24, the final game before the All-Star break. The Sabres then went on an 18–5–5 run, going from 14th in the Eastern Conference back into the eighth and final playoff position on March 24 with a 3–1 win at home against the
Minnesota Wild. On March 27, the Sabres faced the
Washington Capitals for a pivotal game for the final playoff position. The teams entered the game tied at 84 points, with the Capitals holding the tie breaker advantage. The Sabres won the game by a convincing 5–1 score. In the second period of the game, the Sabres were ahead 3–1 and down injuries to two defensemen.
Christian Ehrhoff and
Andrej Sekera were both injured in the period and the Capitals were going on the power play when
Robyn Regehr took a hooking penalty. The penalty left the Sabres with only three available defensemen. On the ensuing power play,
Alexander Ovechkin bobbled a pass at the blue line, where Jason Pominville took the puck and scored a short-handed goal to put the Sabres up 4–1. Ryan Miller made 44 saves, improving to a personal record of 8–0–2 in his last ten games and 14–1–3 in 18 games. The win put Buffalo in sole possession of the eighth playoff spot and even in games with Washington. The Sabres' position in eighth place was short lived, however, due to two consecutive regulation losses, first at home to
Pittsburgh and then at
Toronto. At home on the back end of the home and home with Toronto, the Sabres fell behind 3–0 in the first period and 5–3 in the third. The Sabres then rallied to score two goals in the final five minutes of the third to tie the game at five. In overtime,
Dion Phaneuf took a delay of game penalty, where
Derek Roy ended the game on the ensuing power play with his second goal of the game. The win pulled Buffalo even in points with Washington at 88. Washington still held the tie breaker advantage, with each team having two games left to play. The Sabres would go on to pick up only one point in their final two games, ultimately failing to make the playoffs. On April 3, 2012, following their final regular season home game, the Sabres announced a new record for average paid attendance of 18,272 per home game. ==Playoffs==