Schedule :
Note: Intra-division opponents are in
bold text.
Game summaries Week 1: vs. Seattle Seahawks The Cardinals began their season at home against their divisional rival Seahawks with quarterback John Skelton at the starting helm. The team started their season 1–0 despite Skelton finishing the game 14/28 for 149 yards and an interception. Kevin Kolb later on made an appearance in relief of Skelton going 6/8 for 66 yards and a touchdown pass.
Week 2: at New England Patriots In a huge upset at Gillette Stadium, the Cardinals beat the Patriots to become 2–0. This was the Cardinals' first win against the Patriots since 1991. This would be their last win over New England until
2024.
Week 3: vs. Philadelphia Eagles With the win, the Cardinals started 3–0 for the first time since
1974.
Week 4: vs. Miami Dolphins Week 5: at St. Louis Rams This was the Cardinals' 700th loss. They became the first team in NFL history to do this.
Week 6: vs. Buffalo Bills With the tough loss, the Cardinals fell to 4–2 and also with the Seahawks' win over the Patriots and the 49ers' loss to the Giants, the team remained in a tie for first place in the NFC West.
Week 7: at Minnesota Vikings Week 8: vs. San Francisco 49ers Week 9: at Green Bay Packers Losing their fifth straight game of the season by remaining winless at Lambeau Field (0–7), the Cardinals headed into their bye week at 4–5.
Week 11: at Atlanta Falcons Week 12: vs. St. Louis Rams With their 7th straight loss the Cardinals were swept by the Rams and fell to 4-7.
Week 13: at New York Jets In a game most remembered as possibly the worst QB duel in NFL history, the Cardinals fell 7-6 marking their 8th straight loss.
Week 14: at Seattle Seahawks With the loss, the Cardinals were not only eliminated from postseason contention by falling to 4–9, but the 58-point loss was the worst in franchise history. They committed 8 turnovers, which was the most that the Cardinals have ever committed in a game. Arizona had only 154 yards of total offense while the defense gave up 493 yards. The Cardinals also became the first team in NFL history to lose 9 consecutive games after starting 4–0.
Week 15: vs. Detroit Lions With this win, the Cardinals ended their 9 game losing streak.
Week 16: vs. Chicago Bears Week 17: at San Francisco 49ers With this loss, the Cardinals surpassed
the 1989 Chicago Bears for the worst record by an NFL team starting 4–0. ==Standings==