The 2012 Brussels Open was a women's tennis tournament played on outdoor clay courts. It was the 2nd edition of the Brussels Open, and was part of the Premier-level tournaments of the 2012 WTA Tour. The event took place at the Royal Primerose Tennis Club in Brussels, Belgium, from 19 May through 26 May 2012. First-seeded Agnieszka Radwańska won the singles title.