The 2012 Valencia Open 500 was a men's tennis tournament played on indoor hard courts. It was the 18th edition of the Valencia Open, and part of the 500 Series of the 2012 ATP World Tour. It was held at the Ciutat de les Arts i les Ciències in Valencia, Spain, from 20 October through 28 October 2012. This was the last tournament before the retirement from tennis of Juan Carlos Ferrero. First-seeded David Ferrer won the singles title.