Regular season Week 1: at Denver Broncos The Colts began the season on the road against the defending
AFC champion Denver Broncos. The Colts began the game on offense, driving down to the Broncos' 36-yard line. However, following a delay of game penalty, they were forced to punt.
Peyton Manning led the Broncos' offense on a 16-play drive, but would settle only for a field goal, giving Denver a 3–0 lead. An
Andrew Luck interception on the Colts' ensuing offensive possession set the Broncos up at midfield and would lead to a touchdown on a pass from Manning to
Julius Thomas to give the Broncos a 10–0 lead. After a three and out from the Colts' offense, Manning and the Broncos again take advantage and drive 83-yard to score on another Thomas touchdown reception. Late in the second quarter, the Broncos again scored on a touchdown pass from Manning to Thomas and extended Denver's lead to 24–0 with two minutes remaining in the half. The Colts put together an 8-play, 80-yard drive to end the half and scored their first points on a 9-yard run from Luck, making the score 24–7 in favor of Denver at halftime. The Broncos' began the second half on offense, though they were eventually forced to punt. After driving into the red zone on their first offensive possession of the half, the Colts' failed to convert a fourth down on the goal line and turned the ball over on downs. The Colts' next offensive possession would again stall in the red zone, with the Colts settling for an
Adam Vinatieri field goal, cutting the Bronco lead to 24–10. A 48-yard drive early in the fourth quarter gave the Broncos as 31–10 lead after a
Montee Ball touchdown run. The Colts would respond on their next drive with a touchdown pass from Luck to
Dwayne Allen, cutting the Broncos' lead down to two scores. The Colts failed to take advantage of a recovered onside kick, after Luck threw an interception in Broncos' territory. After the Colts defense forced a three and out, Luck again drove the Colts down to the goal line, eventually scoring on a touchdown pass to
Hakeem Nicks. After again stopping the Broncos' offense, the Colts received the ball with a little under three minutes remaining in the game and a change to tie the game. Though the Colts would drive into Bronco territory, the drive would end after a failed fourth down pass attempt from Luck to
Reggie Wayne. The Colts scored on their second offensive possession of the third quarter, with a field goal from Vinatieri, giving the Colts a two possession lead at 20–6. Philadelphia responded on their next drive after driving 80 yards in seven plays and scoring on 1-yard touchdown run from
LeSean McCoy, making the score 20–13. After a fumble by running back
Trent Richardson on the Colts next offensive possession, set up the Eagles to tie the game on a 19-yard touchdown run from
Darren Sproles. On the first possession of the fourth quarter, the Colts offense drive 80 yards to reclaim the lead on a pass from Luck to Bradshaw and giving the Colts a 27–20 lead. The Colts failed to put away the Eagles, after Luck threw an interception during a play that involved a controversial no-call penalty on the Colts next offensive drive, which set up a five play drive, that allowed the Eagles to tie the game at 27–27. After a three and out on the next Colts possession, the Eagles took possession of the ball at their own forty yard line. Foles and the Eagles offense drove 42 yards to the Colts 18 yard line, with Parkey hitting a 36-yard field goal as time expired, which gave the Eagles the 30–27 victory. After struggling to move the ball in the first half, the Jaguars replaced quarterback
Chad Henne with rookie
Blake Bortles. The Jaguars were able to convert a first down on their first drive of the half, though they were forced to punt following a penalty that sent them back to midfield. On the Jaguars' next possession, they again drove into Colts' territory, enough to get their first points of the game on a 41-yard field goal from
Josh Scobee. At the end of the third quarter, the Colts continued to hold a commanding 30–3 lead. The Colts scored their first points of the second half on a pass from Luck to
Hakeem Nicks early in the fourth quarter. Bortles threw his first career touchdown pass on the Jaguars' next possession, throwing it to
Allen Hurns. With the large lead late in the game, the Colts replaced Luck with backup quarterback
Matt Hasselbeck. Late in the fourth quarter the Colts defense extended the lead, with an interception returned for a touchdown by
Greg Toler. A Bortles pass to
Cecil Shorts III was the last scoring play of the game, giving the Colts the 44–17 win. The game marked the first win of the season for the Colts and improved their overall record to 1–2. As of
2025, this remains the last time the Colts defeated the Jaguars in Jacksonville.
Week 4: vs. Tennessee Titans Following their first win of the season, the Colts faced another divisional rival in the
Tennessee Titans. After being forced to punt on their first offensive drive, the Colts' defense forced a fumble that was recovered by
Ricky Jean-Francois and set up the Colts inside Titan territory. After a 37-yard pass from quarterback
Andrew Luck to
T. Y. Hilton set the Colts up at the one yard line,
Trent Richardson scored on the next play, putting the Colts up 7–0. An onside kick gave the ball back to the Colts, which led to an eleven play, 44-yard drive that ended in a touchdown pass from Luck to
Dwayne Allen. The Colts' defense again forced a turnover on the Titans' next possession, with
Charlie Whitehurst throwing an interception to
Mike Adams. Luck and the Colts' offense again drove down the field, though this time having to settle for a field goal, extending the lead to 17–0. Tennessee scored their first points midway through the second quarter on a
Ryan Succop. The Colts responded on their next possession with a 30-yard field goal from
Adam Vinatieri. A Luck interception late in the half, set up the Titans in Colts' territory and allowed them to score on a pass from Whitehurst to
Delanie Walker, cutting the Colts' lead to 20–10 at halftime. The Colts' scored on their first offensive possession of the second half, on a 28-yard touchdown pass from Luck to
Reggie Wayne and then later in the quarter on a pass from Luck to
Coby Fleener, extending the Colts' lead to 34–10. Tennessee responded with an eight play, 80-yard drive that ended with a touchdown run from
Bishop Sankey. Luck completed his fourth touchdown pass of the game early in the fourth quarter, this time on a 15-yard pass to
Ahmad Bradshaw, giving the Colts a 41–17 lead. Late in the game, Adams again forced another turnover, with
Zach Mettenberger throwing the interception. With the win, the Colts improved to 2–2.
Week 5: vs. Baltimore Ravens Following back to back wins over division rivals, the Colts' returned to
Lucas Oil Stadium to face the
Baltimore Ravens.
Andrew Luck and the Colts' offense drove 59 yards on their first offensive possession, with the drive ending on a turnover after the Colts failed to convert a fourth down. On the first play of the Ravens' offensive possession,
Steve Smith fumbled the ball, which was then recovered by
Montori Hughes of the Colts. The Colts settled for a 38-yard field goal by
Adam Vinatieri, giving then an early 3–0 lead. A muffed punt return by
Jacoby Jones resulted in a second Ravens' turnover, however, on the ensuing Colts' drive,
Haloti Ngata intercepted Luck, their first turnover of the game. After a stalled Ravens' drive early in the second quarter, the Colts drove 70 yards in 20 plays, though they again settled for a Vinatieri. The Ravens responded, scoring on a 52-yard field goal from
Justin Tucker as time expired, cutting the Colts' lead to 6–3 at halftime. The Ravens opened the second half on offense and committed their third turnover on a
Joe Flacco interception by
Vontae Davis. The Colts' took advantage of the turnover, by scoring their first touchdown on a Luck touchdown pass from
Dwayne Allen, giving them a 13–3 lead. The Ravens' defense again stepped up later in the third quarter, forcing the Colts' second turnover on a Luck interception by
C.J. Mosley, which resulted in a second Tucker field goal. The Colts again extended their lead early in the fourth quarter on a Luck touchdown run, which gave the Colts a two possession lead at 20–6. The Ravens closed the gap again on their ensuing possession,
Justin Forsett 11-yard touchdown run, cutting the lead back to one possession. After driving down to the Ravens' 10-yard line, Colts running back
Ahmad Bradshaw fumbled the ball, giving the Ravens possession with under two minutes remaining in the game. The Colts' defense forced a turnover on downs and sealed the 20–13 win. The Texans scored the first points on the second half on their offensive possession, scoring on another Foster touchdown run, which cut the Colts lead to one possession. Luck and the Colts responded on their ensuing possession, driving 80 yards and scoring on a 33-yard touchdown pass from Luck to
T. Y. Hilton. After a failed two-point conversion attempt, the Colts led 33–21 at the end of the third quarter. Midway through the fourth quarter, Texans' defensive end
J. J. Watt forced a fumble that was returned for 45-yards for a touchdown and again closing the Colts' lead to one possession. Fumbles on the two ensuing Texan possessions ensured the Colts' 33–28 win. With the win, the Colts improved to 4–2, winning four straight games, as well as their tenth straight win within the division, dating back to the
2012 season.
Week 7: vs. Cincinnati Bengals The Colts franchise reached its 500th win, counting regular season and playoffs.
Week 8: at Pittsburgh Steelers Week 9: at New York Giants Week 11: vs. New England Patriots Week 12: vs. Jacksonville Jaguars With the win, the Colts improved to 7–4. This marks the last time Indianapolis successfully swept Jacksonville.
Week 13: vs. Washington Redskins Week 14: at Cleveland Browns Week 15: vs. Houston Texans With the win, the Colts clinched the AFC South title for a second consecutive season while improving to 10–4 and 13–0 against the Texans at home. As of 2025, this marks the last time the Colts clinched the AFC South.
Week 16: at Dallas Cowboys Week 17: at Tennessee Titans With the win, the Colts finished the season 11–5 for the third straight year, good enough for the AFC's #4 seed. This would be their 13th straight win over a division rival as they improved to 16–2 against divisional opponents overall under Andrew Luck.
Postseason AFC Wild Card Playoffs: vs. #5 Cincinnati Bengals As of
2025, this is the last playoff game played at Lucas Oil Stadium.
AFC Divisional Playoffs: at #2 Denver Broncos With the upset win, the Colts defeated their former quarterback Peyton Manning and they advanced to the AFC Championship. As of 2025, this marked the last time the Colts won a Divisional Round game.
AFC Championship: at #1 New England Patriots ==Standings==