Race organisers initially introduced major changes to the route for the 2014 edition of the race, with the new
Pompeiana climb being introduced between the existing
Cipressa and
Poggio climbs in the climax of the race, although the earlier climb of Le Mànie was taken out. This was seen to tip the balance of the race in favour of puncheurs and climbers rather than sprinters, with many sprinters including 2009 winner
Mark Cavendish () stating they would not compete. However, in February 2014 race organisers announced the new climb would not be used after all, due to poor weather conditions. With no replacement climb, the route now resembled that of the 2007 edition, and seemed to now favour sprinters due to a flatter route than in previous years. Subsequently, the likes of Cavendish and
André Greipel () decided they would compete in the first monument of the season.
Peter Sagan of was seen as one of the top favourites going into the race, due to his all round sprinting and hill climbing abilities. Cavendish, Greipel and 's
John Degenkolb were considered favourites should the race end in a bunch sprint, whilst the likes of
Fabian Cancellara (),
Philippe Gilbert of the , 's
Simon Gerrans and
Tom-Jelte Slagter of would be looking to set up victory by dropping the sprinters on the final climbs. Gerrans did not start the race, after being ruled out the day before due to illness. ==Teams==