, who rode for in the breakaway and finished seventh
(pictured at the 2015 Tour de France) Before the race began, there was a minute's silence in memory of
Antoine Demoitié, a rider who had been killed in a crash with a motorbike during Gent–Wevelgem. After , the riders arrived in
Hooglede, the birthplace of
Daan Myngheer, a rider for who had died following a heart attack in the
Critérium International; the peloton rode slowly through the town in memory of him. The day's
breakaway took a long time to form: over an hour into the day's racing, with more than covered, a six-man move broke free. The riders were
Hugo Houle (),
Federico Zurlo (),
Imanol Erviti (
Movistar),
Lukas Pöstlberger (Bora–Argon 18),
Gijs Van Hoecke (Topsport Vlaanderen–Baloise) and
Wesley Kreder (Roompot–Oranje Peloton). They earned a lead of over four minutes, but broke apart as the day's climbs began. , wearing the rainbow-striped jersey of the reigning world champion
(pictured at the 2016 Omloop Het Nieuwsblad) On the Molenberg, with more than remaining, a hard effort by
Tony Martin (Etixx–Quick-Step) caused a split in the main peloton, with 25 riders in the front group, but the groups came back together shortly afterwards.
André Greipel (Lotto–Soudal) and
Nils Politt (Katusha) then attacked on the Leberg and were allowed to go; they were followed by
Dmitriy Gruzdev () and
Dimitri Claeys (). These four riders joined up with Houle, Erviti and Van Hoecke from the original break; Houle was dropped soon afterwards to form a six-man leading group, which had a two-minute lead at the foot of the second ascent of the Oude Kwaremont. On the climb,
Stijn Vandenbergh (Etixx–Quick-Step) and
Dylan van Baarle () attacked from the peloton. Another group, including Sep Vanmarcke and Ian Stannard, attacked before the Koppenberg. Stannard then went solo over the top of the climb. Meanwhile, Vandenbergh and Van Baarle caught up with the group of leaders. There were several more attacks before the climb of the Taaienberg, where a small group of favourites formed and quickly caught Stannard. Shortly afterwards, with remaining, Michał Kwiatkowski and Peter Sagan attacked together and were joined by Sep Vanmarcke. They crossed the Kruisberg together and caught the remainder of the breakaway with remaining, 40 seconds ahead of the peloton. On the final climb of the Oude Kwaremont, Kwiatkowski was unable to follow Sagan and Vanmarcke, while Cancellara rode clear of the peloton. Sagan was first to the summit with Vanmarcke; Cancellara was twelve seconds behind. Cancellara was then caught by Niki Terpstra, Erviti and Claeys. On the final climb, the Paterberg, Sagan rode away from Vanmarcke, who was caught by Cancellara at the top of the climb. They rode in pursuit of Sagan, who had a 15-second lead at the summit. The chasing pair were unable to bring Sagan back and he rode to the finish to win his first Monument. Cancellara finished second, 25 seconds back, with Vanmarcke allowing him to take second place. Kristoff won the sprint for fourth place, ahead of
Luke Rowe (Sky), 49 seconds behind Sagan. ==Result==