Market2016 Western & Southern Open – Women's singles
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2016 Western & Southern Open – Women's singles

Karolína Plíšková defeated Angelique Kerber in the final, 6–3, 6–1 to win the women's singles tennis title at the 2016 Cincinnati Masters. It was her sixth WTA Tour singles title.The two would play each other three weeks later, in the final of the US Open; Kerber would avenge her loss by beating Plíšková in three sets.

Seeds
All seeds received a bye into the second round. ==Draw==
Draw
Finals Top half Section 1 Section 2 Bottom half Section 3 Section 4 ==Qualifying==
Qualifying
Seeds Qualifiers Lucky losers Qualifying draw First qualifier Second qualifier Third qualifier Fourth qualifier Fifth qualifier Sixth qualifier Seventh qualifier Eighth qualifier Ninth qualifier Tenth qualifier Eleventh qualifier Twelfth qualifier ==References==
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