In 2016, the Cardinals finished as champions of the
Atlantic Coast Conference with a record of 46–10, 22–8 in conference play, in their second season in the conference. They qualified for the
2016 Atlantic Coast Conference baseball tournament, where they played in Division B of inter-conference tournament play. The Cardinals would finish 1–2 in the tournament, not advancing to the conference tournament finals. With the Cardinals finishing the season as regular season champs of the Atlantic Division of the ACC, they would qualify for the
2016 NCAA Division I baseball tournament, and were selected as hosts of the Louisville regional and Louisville Super Regional, if they advanced to that round. The Cardinals would wins three straight matches in the Louisville Regional and would advance to the Super Regional (of which they were hosts) by defeating
Western Michigan 6–1,
Ohio State 15–3, and
Wright State 3–1. In the Super Regional, Louisville hosted
UC Santa Barbara in a best-of-three matchup. Louisville would lose the first two games to UC Santa Barbara, ending their playoff run. ==Roster==