Round of 16 The draw for the Round of 16 and subsequent phases was held on 28 May 2018. Starting from this round, the order of legs in each tie will depend on the number assigned to the second round tie won by each team, with the team with the highest number in each tie hosting the second leg. The first legs were played from 22 to 24 June 2018 and the second legs were played from 29 June to 2 July 2018.
First leg Second leg Quarterfinals The first legs were played on 7 and 8 July 2018, while the second legs were played on 13 and 14 July 2018.
First leg Second leg Semifinals The first legs were played on 8 September 2018, and the second legs were played on 12 and 13 October 2018.
First leg Second leg Finals For the first time since 2011, the finals were played in a
two-legged tie format. ----
Palestino won 4–2 on aggregate. == Top goal scorers==