The 2020–21 Mid-American Conference men's basketball season began with practices in October 2020, followed by the start of the 2020–21 NCAA Division I men's basketball season in November. Conference play began in January 2021 and concluded in March 2021. In a season limited due to the ongoing COVID-19 pandemic, Toledo won the regular season title with a conference record of 15–4. Ohio won the MAC tournament and represented the MAC in the NCAA tournament where they defeated No. 4-seeded Virginia in the first round before falling to No. 5-seeded Creighton in the second round. Toledo went to the NIT where they lost to Richmond in the first round.