The 2020–21 Moldovan National Division was the 30th season of top-tier football in Moldova. The season started on 3 July 2020 and ended on 26 May 2021. Sheriff Tiraspol were the defending champions. The winners of the league this season earned a spot in the first qualifying round of the 2021–22 UEFA Champions League, and the second, third and fourth placed clubs earned a place in the first qualifying round of the 2021–22 UEFA Europa Conference League.