The team played its first game of the season on January 15, 2021, defeating the "Battle of Ontario" rival
Toronto Maple Leafs at the
Canadian Tire Centre. It was the team's first game in 310 days. The team had nine new players in the lineup, including 2020 first-round pick
Tim Stutzle. The Senators proceeded to lose nine games in a row in January, before defeating the
Montreal Canadiens on February 4. On February 15, 2021, the Senators made their first-ever comeback in team history from being four or more goals behind. The team was down 5–1 in Toronto to the Maple Leafs near the end of the second period.
Nick Paul started the comeback with a shorthanded goal. In the third period,
Artyom Zub scored his first NHL goal on a breakaway after exiting the penalty box.
Connor Brown later scored just after a power play, and
Evgenii Dadonov scored twice; first to tie the game with two minutes to play with Ottawa goalie
Marcus Hogberg on the bench for an extra attacker and then scored on a breakaway to win the game 6–5 in overtime. However, he made a save while in the crease to stop Toronto's potential overtime goal. The Senators goaltenders suffered a rash of injuries, causing the team to use five goaltenders. Matt Murray, Marcus Hogberg and
Joey Daccord were all injured at one time. Daccord's injury ended his season. The Senators called up
Filip Gustavsson for his first NHL game and picked up
Anton Forsberg on waivers. Prior to the trade deadline, the Senators picked up
Ryan Dzingel for his second term with the team, trading Alex Galchenyuk and Cedric Paquette to the Carolina Hurricanes. At the trade deadline, well out of a playoff spot, the Senators traded several veterans for draft picks. Erik Gudbranson went to the Nashville Predators for
Brandon Fortunato and a 2023 seventh-round draft pick.
Mike Reilly was traded to the
Boston Bruins for a third-round pick in the
2022. Braydon Coburn was traded to the
New York Islanders for a seventh-round pick in the 2022 NHL Entry Draft. Connor Brown set a team record, scoring in eight consecutive games, beating the previous record of six, held by
Jason Spezza and
Daniel Alfredsson.
Standings Schedule and results The regular season schedule was published on December 23, 2020.
Legend: ==Player statistics==