The 2020–21 Telenet UCI Cyclo-cross World Cup was a season long cyclo-cross competition, organised by the Union Cycliste Internationale (UCI). The UCI Cyclo-cross World Cup took place between 4 October 2020 and 24 January 2021. In 2020, the UCI redesigned the UCI Cyclo-cross World Cup, expanding the total number of races to 14. The defending champions were Toon Aerts in the men's competition and Annemarie Worst in the women's competition.