Schedule The 49ers'
2020 schedule was announced on May 7. It got so bad the team's MRI truck broke down. The win brought the 49ers to 1-1 on the season.
Week 3: at New York Giants With
Jimmy Garoppolo sidelined,
Nick Mullens made his first start since
2018. He threw for 343 yards and a touchdown in a blowout win over the Giants, bringing the 49ers up to 2-1 for the season.
Week 4: vs. Philadelphia Eagles With this loss, the 49ers dropped to 2–2.
Nick Mullens struggled mightily in the game with two interceptions, one of which was returned by
Alex Singleton for a touchdown, and was benched afterwards for
C. J. Beathard. The 49ers drove all the way to within field goal range down by 5, but the clock ran out.
Week 5: vs. Miami Dolphins With this embarrassing loss, the 49ers dropped to 2–3, already matching last season's loss total.
Jimmy Garoppolo returned from injury but struggled mightily with 2 interceptions, leading to him being benched at halftime for
C. J. Beathard.
Week 6: vs. Los Angeles Rams The 49ers bounced back from the previous week.
Jimmy Garoppolo threw 3 touchdowns and 268 yards and the 49ers defense was able to hold a red-hot Rams offense in check. With this win, they improved to 3–3, and won their third straight meeting against the Rams.
Week 7: at New England Patriots This was quarterback
Jimmy Garoppolo's first return to New England since the Patriots traded him to the 49ers in October 2017. Garoppolo played for the Patriots from 2014 to 2017, and was part of their
2014 and
2016 Super Bowl-winning teams. Jimmy's victorious return brought the 49ers up to 4-3 on the season.
Week 8: at Seattle Seahawks At one point, the 49ers were down 7-30. Despite outscoring the Seahawks 20-7 for the rest of the game, the 49ers dropped to 4-4.
Week 9: vs. Green Bay Packers In a rematch of the NFC Championship the previous season. Aaron Rodgers threw for 305 yards and 4 touchdowns as the Packers went up 34–3 before the 49ers scored two meaningless touchdowns to make the final score 34–17 and dropping the 49ers to 4–5. As of week 9, the 49ers have a league high 24 players on the reserve lists. Due to
COVID-19 pandemic restrictions, this would be the final game at Levi's Stadium for the season.
Week 10: at New Orleans Saints With the loss, the 49ers dropped to 4-6.
Week 12: at Los Angeles Rams The 49ers returned from their bye week with some much-needed reinforcement returning from injury: on offense, Raheem Mostert scored a touchdown and 43 yards rushing and Deebo Samuel had 133 receiving yards; on defense, Richard Sherman contributed by grabbing his first interception of the season. The game was largely a defensive struggle. The two teams had four combined turnovers in the first quarter, and the only points scored in the first half came on a Raheem Mostert touchdown and a Matt Gay field goal. Early in the third quarter, the 49ers padded their lead to fourteen points with Javon Kinlaw's pick six and a Robbie Gould field goal. However, the momentum changed quickly as Aaron Donald forced a fumble on Raheem Mostert and it was returned for a touchdown by Troy Hill. The Rams soon scored again on a touchdown run from Cam Akers to take a three-point lead. The Rams' final drives quickly turned to punts while Nick Mullens led the 49ers on two drives resulting in field goals, including the 42-yard game winner by Robbie Gould with no time on the clock. With the win, the 49ers swept the Rams for the second straight year and bringing their record to 5-6
Week 13: vs. Buffalo Bills Due to the
COVID-19 pandemic in
Santa Clara County halting all contact sports the 49ers decided to use
State Farm Stadium for 2 games. However, the result dropped the 49ers to 5-7 on the season
Week 14: vs. Washington Football Team In a game that saw a returning Alex Smith to face the team that drafted him for the final time and Smith's revenge dropped the 49ers to 5-8 on the season.
Week 15: at Dallas Cowboys The 49ers traveled to Dallas hoping to keep their season alive, but struggled throughout the game. The 49ers immediately trailed 17–7, and turned the ball over 4 times against one of the worst defenses in the NFL. Despite fighting back and forth after tying the game, the 49ers never had the lead. San Francisco also allowed Cowboys wide receiver CeeDee Lamb to return a kickoff for a touchdown, which sealed the 49ers' loss. This loss, combined with the Cardinals' victory over the Eagles, eliminated the 49ers from playoff contention. The 49ers also clinched a losing season for the 7th time in 10 years. As of 2025, this was the Niners most recent loss to the Cowboys.
Week 16: at Arizona Cardinals With this win, the San Francisco 49ers finished 5-3 in away games and brought their record up to 6-9 on the season.
Week 17: vs. Seattle Seahawks With this loss, the 49ers finished 1-7 at home and are 1-5 in their last 6 games against Seattle. The Defending NFC Champions would finish their season in dismissal 6-10 record and last place in the NFC West for the first time since 2017.
Standings Division Conference ==Notes==