The 2021–22 Columbia Lions women's basketball team represented Columbia University during the 2021–22 NCAA Division I women's basketball season. The Lions, led by sixth-year head coach Megan Griffith, played their home games at Levien Gymnasium in New York City, New York and were members of the Ivy League. They finished the season 25–7, 12–2 in Ivy League play, to finish in second place behind Princeton. They advanced to the Ivy League women's tournament finals but lost to Princeton 59–77. The Lions accepted a bid to play in the 2022 WNIT and made it to the quarterfinals, losing to Seton Hall 75–78. This was the first time an Ivy League team reached the WNIT quarterfinals.