Eighteen teams competed in the league; the 15 from
the previous season and the 3 winners of the Division One League zones. The promoted teams were
Bibiani Gold Stars and
Accra Lions, who both achieved promotion for the first time.
RTU returned to the league for the first time since their relegation in 2013.
Stadiums and locations {{Location map+|Ghana|float=right|width=340|caption=Location of the 2021–22 Ghana Premier League teams|places= {{Location map~ |Ghana |lat=5.035768
Club managers and captains The table lists club managers. Managerial changes == League table ==