The 2021–22 season was Milton Keynes Dons' 18th season in their existence, and the club's third consecutive season in League One. The club also competed in the FA Cup, EFL Cup and EFL Trophy.
Managerial change
On 1 August 2021, manager Russell Martin departed the club to take up the vacant managerial position at Swansea City, with the buyout clause in his contract activated. A successor was announced on 13 August 2021, with Liam Manning being revealed as the club's first ever Head Coach. ==Pre-season friendlies==
League OneLeague tableResults summaryResults by matchdayMatchesPlay-offsMatchesFA CupMatchesEFL CupMatchesEFL TrophySouthern Group C table {{#invoke:Sports table|main|style=WL OT Matches ==Player details==
Player details
: ''Note: Players' ages as of the club's final match of the 2021–22 season.'' ==Transfers==
Transfers
Transfers in Loans in Loans out Transfers out == Awards ==