The 2021–22 Newport County A.F.C. season was the club's ninth consecutive season in the EFL League Two. It was Newport's 69th season in the Football League and 101st season of league football overall. Alongside League Two, they also competed in the FA Cup, the EFL Cup, the EFL Trophy and the Welsh League Cup. On 25 August 2021 Newport County faced Southampton of the Premier League in the second round of the 2021–22 EFL Cup but they lost heavily 8–0. Newport finished the 2021–22 League Two season in 11th place.