Main •
Leo Wu (Shi Xiaosong (young) ) as Xiao Yan () • A martial arts genius. Younger son of the Xiao family, Disciple of the Medicine Lord. Lost his abilities at the age of nine after his mother's death but soon makes great advances after his encounter with his teacher, Yao Chen. •
Lin Yun as Xiao Xun'er () • Descendant of the Gu tribe.She was adopted by Xiao Yan's family since young and is loyal toward him. She has had a crush on Xiao Yan since their childhood due to Xiao Yan sneaking into her room to use his Dou Qi to strengthen her bones. Becomes the Dragon Mother of the Gu Clan. •
Li Qin as Xiao Yixian () • Daughter of the Ice King. Xiao Yan's bosom friend. She has a body filled with different kind of poison. •
Baron Chen as Yao Chen () • The Medicine Lord, previous master of Xing Yun pavilion. Xiao Yan's teacher. Also Xiao Yan's Mother's former teacher. •
Xin Zhilei as Medusa () • Queen of the Snake tribe. • Liu Meitong as Nalan Yanran () • Descendant of Nalan tribe. Young mistress of Yunlan sect. Xiao Yan's former fiancee, who canceled their engagement after he lost his abilities. However, she accepted a three year agreement from Xiao Yan to fight for their respective clan's prides.
Supporting Jianan Academy • Su Qianwei as Ruo Lin () • Grandmaster of Taidou. Xiao Yan and Xiao Xuner's teacher. Known for her beauty and good morals. • Ling Xiaosu as Han Feng () • Master of Xing Yun pavilion. Elder of Jianan Academy. Yao Chen's disciple. Traitor working alongside the Soul Hall and causing Xiao Yan's Mother's death. •
Xiao Zhan as
Lin Xiuya () • Leader of the "Wolf Teeth" forces. He is skilled in hunting magical beasts. •
Wu Jiacheng as
Hao Tian () • Known as "Bloody Sword". A talent at refining medicine. •
Peng Chuyue as
Han Xian () • Leader of the Medicine sect and then member of the Yan Sect. •
Gu Jiacheng as
Hu Jia () • The character in the novel was the grand-daughter of the vice-principal of Jianan Academy, known as "Demon Girl". Changed to a male in the television adaptation. • Hua Cheng as Bai Cheng () • Arrogant Senior Disciple who despises Xiao Yan.
Xiao Tribe •
Yu Rongguang as Xiao Zhan () • Leader of Xiao tribe. Xiao Yan's father. • Li Shen as Xiao Ding () • Xiao Yan's elder brother. Leader of Mo Tie army, a group of outlaws who fight for good. • Yan Xi as Xiao Li () • Xiao Yan's second brother and Vice-Leader of Mo Tie Army.
Gu Tribe •
Carman Lee as Gu Wenxin () • Xiao Yan's mother; Yao Chen's disciple. Forced to commit suicide after being falsely labelled as a Traitor • Li Zifeng as Gu Yuan () • Gu Wenxin's brother; Xiao Xuner's father. • Miao Yilun as Gu Tianyi () • Xiao Xuner's brother.
Nalan tribe (Yunlan Sect) • Norman Chui as Nalan Jie () • Elder of Nalan tribe. Nalan Yanran's grandfather. •
Su Qing as
Yun Yun () • Eldest disciple of Yunlan Sect. Nalan Yanran's teacher. • Zeng Jiang as Yun Shan () • Former leader of Yun Lan sect. Yun Yun's teacher. • Cheng Haofeng as Gu He () • Number one medicine practitioner of the world. Elder of Yun Lan sect. Yun Yun's admirer.
Mite'er tribe • Qiu Xinzhi as Hai Bodong () • One of the top ten experts of Jia Ma Empire. Grand elder of Mite'er tribe. Known as the "Ice King". Xiao Yixian's father. • Zhu Xiaoyu as Mi Tengshan () • Leader of Mite'er tribe and Elder of Jianan Academy.
Snake tribe • Du Chun as Mobasi () • Leader of Snake Tribe. • Xu Kelong as Qing Lin () • Female general of Snake tribe.
Others • Guo Xiaofeng as Fa Ma () • Imperial advisor of Chuyun kingdom. • Chen Zexi as Ye Lan () • Crown prince of Chuyun kingdom. • Guo Ziyu as Fan Ling () • Leader of Blood Sect. • Miao Haojun as Ge Ye () • Gong Rui as Yun Zhen () • Dou Bolin as Mo Li () • Wang Wanjuan ==Production==