U21 play-offs Since Jong Volendam finished as the lowest reserve team in the regular league season, they had to play a promotion-relegation play-offs tie against the champions of the Under-21 league, Almere City U21, for a spot in the
2022–23 Tweede Divisie.
Derde Divisie promotion/relegation playoffs Since
Kozakken Boys and
GVVV finished 16th and 17th respectively, they will have to play relegation playoffs against teams from the
Derde Divisie for one spot in the
2022–23 Tweede Divisie. That means at least one team will be relegated from the Tweede Divisie through playoffs.
Bracket Quarterfinals First legs Second legs Semifinals First legs Second legs Final First leg Second leg ==Top scorers==