Legends: AM – AAFU (amateur) competitions (IV tier), 2L – Second League (III tier), 1L – First League (II tier), PL – Premier League (I tier)
First preliminary round (1/128) In this round, 8 clubs from the
Second League and 2 semifinalists of the
2020–21 Ukrainian Amateur Cup entered the competition. The draw was held on 27 July 2021.
Second preliminary round (1/64) In this round, 16 clubs from the
First League and 23 clubs from the
Second League enter the competition and join the 5 winners of the First preliminary round (3 clubs from Second League, 2 – amateurs). The draw was held on 6 August 2021.
Third preliminary round (1/32) In this round participate the 22 winners of the Second preliminary round (10 clubs from First League, 12 – Second League). The draw was held on 19 August 2021.
Round of 32 In this round, 11 clubs from the
Premier League (lower ranked) enter the competition and join the 11 winners of the Third preliminary round (7 clubs from First League, 4 – Second League). The draw was held on 3 September 2021.
Round of 16 In this round, rest of 5 clubs from the
Premier League (upper ranked) enter the competition and join the 11 winners of the Round of 32 (8 clubs from Premier League, 2 – First League, 1 – Second League). The draw for round of 16 was held on 24 September 2021.
Quarter-finals This round includes one team from the First League (
Metalist Kharkiv) and 7 clubs from the Premier League. Base date for the matches is 1–2–3 March 2022. The draw for quarter-finals was held on 15 December 2021.
Semi-finals The draw for semi-finals and final was meant be held on 3 March 2022.
Final == Top goalscorers ==