The 2021–22 Villanova Wildcats men's basketball team represented Villanova University in the 2021–22 NCAA Division I men's basketball season. Led by head coach Jay Wright in his 21st and final year of coaching, the Wildcats played their home games at the Finneran Pavilion on the school's campus in the Philadelphia suburb of Villanova, Pennsylvania and Wells Fargo Center as members of the Big East Conference. They finished the season 30–8, 16–4 in Big East play to finish in second place. They defeated St. John's, UConn, and Creighton to win the Big East tournament championship. As a result, they received the conference's automatic bid to the NCAA tournament as the No. 2 seed in the South region. They defeated Delaware, Ohio State, Michigan, and Houston to advance to the Final Four. There they lost to eventual national champion Kansas.