The 2021 Buffalo Bulls football team represented the University at Buffalo as a member of the Mid-American Conference (MAC) during the 2021 NCAA Division I FBS football season. Led by first-year head coach Maurice Linguist, the Bulls compiled an overall record of 4–8 with a mark of 2–6 in conference play, tying for fourth place in the MAC's East Division. The team played home games at University at Buffalo Stadium in Amherst, New York.