The competition followed a similar format to the originally proposed
2020 edition with four rounds and regional pairings in the first two rounds. For the first time in the Canadian Championship, each tie was played as a single-leg fixture. CF Montréal, Forge FC, and Toronto FC entered the tournament in the quarter-finals due to their placements in the 2019 and 2020 editions of the competition. All other teams entered in the preliminary round of the tournament.
A.S. Blainville and
Master's FA were originally supposed to participate in the 2020 edition of the competition, as they won the 2019 editions of the
Première ligue de soccer du Québec and
League1 Ontario, respectively. As the format of the 2020 edition was revised, their participation was postponed to the 2021 tournament.
Distribution ==Qualified clubs==