Novak Djokovic defeated Stefanos Tsitsipas in the final, 6–7(6–8), 2–6, 6–3, 6–2, 6–4 to win the men's singles tennis title at the 2021 French Open. It was his second French Open title and 19th major title overall. Djokovic became the first man to achieve the double career Grand Slam in the Open Era, and the first player in the Open Era to win a major after coming back from two-sets-to-love down in two matches during the same major. Tsitsipas was the first Greek to reach a major final. It also marked the second consecutive year a man trailed by two sets in a major final yet rallied to win, following Dominic Thiem's victory at the 2020 US Open. It was the first time since 2004 that the final went to five sets; on that occasion, Gastón Gaudio also came from two sets down to win the title. The final was a rematch of the previous year's semifinal match, also won by Djokovic.