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2021 Iowa State Cyclones football team

The 2021 Iowa State Cyclones football team represented Iowa State University as a member of Big 12 Conference during the 2021 NCAA Division I FBS football season. Led by sixth-year head coach Matt Campbell, the Cyclones compiled an overall record of 7–6 with a mark of 5–4 in conference play, placing fourth in the Big 12. Iowa State was invited to the Cheez-It Bowl, the Cyclones lost to Clemson. The team played home games at Jack Trice Stadium in Ames, Iowa.

Schedule
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Game summaries
Vs. No. 21 (FCS) Northern Iowa Vs. No. 10 Iowa At UNLV At Baylor Vs. Kansas At Kansas State Vs. No. 8 Oklahoma State At West Virginia Vs. Texas At Texas Tech At No. 13 Oklahoma Vs. TCU Vs. No. 19 Clemson—Cheez-It Bowl ==Coaching staff==
TV ratings
All totals via Sports Media Watch. Streaming numbers not included. † - Data not available. ==References==
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