This section lists instances of unranked teams defeating ranked teams during the season.
Regular season During the regular season, 33 unranked teams have defeated a ranked team. • September 4, 2021: •
Furman 29, No. 25
North Carolina A&T 18 • September 11, 2021: •
Merrimack 35, No. 24
Holy Cross 21 • September 25, 2021 • Holy Cross 45, No. 20
Monmouth 15 •
Eastern Kentucky 35, No. 19
Austin Peay 27 •
UT Martin 34, No. 9
Jacksonville State 31 • October 2, 2021 •
Elon 20, No. 22
Richmond 7 •
The Citadel 35, No. 18
VMI 24 • October 9, 2021 •
Idaho State 27, No. 7
UC Davis 17 •
South Dakota 20, No. 13
North Dakota 13 •
Youngstown State 41, No. 16
Missouri State 33 • October 16, 2021 •
Dartmouth 38, No. 23
New Hampshire 21 •
Chattanooga 21, No. 10
East Tennessee State 16 •
Sacramento State 28, No. 5
Montana 27 •
Stony Brook 34, No. 14
Delaware 17 •
Towson 28, No. 12
Rhode Island 7 • October 22, 2021 •
Columbia 19, No. 25 Dartmouth 0 • October 23, 2021 •
Weber State 35, No. 2
Eastern Washington 34 •
Illinois State 20, No. 15 South Dakota 14 •
McNeese State 28, No. 16
Incarnate Word 20 • October 30, 2021 •
William & Mary 31, No. 4
Villanova 18 •
Maine 45, No. 24 Rhode Island 24 • November 5, 2021 • Dartmouth 31, No. 20т
Princeton 7 • November 6, 2021 •
Portland State 30, No. 24 Weber State 18 • Delaware 24, No. 20т William & Mary 3 • Illinois State 17, No. 13
Northern Iowa 10 OT •
Stephen F. Austin 31, No. 25 Eastern Kentucky 17 • November 13, 2021 •
Alcorn State 31, No. 24
Prairie View A&M 29 •
Furman 37, No. 21 VMI 31 •
Mercer 10, No. 22т Chattanooga 6 • November 20, 2021 •
Southeast Missouri State 31, No. 13
UT Martin 14 •
Nicholls 45, No. 15
Southeastern Louisiana 42 • Youngstown State 35, No. 17
Southern Illinois 18 • Elon 43, No. 25 Rhode Island 28 ==Coaching changes==