2021 Yarra Valley Classic – Singles

The top ten seeds received a bye into the second round. Ashleigh Barty (champion) Sofia Kenin (quarterfinals) Karolína Plíšková (third round) Petra Kvitová (third round) Serena Williams (semifinals, withdrew because of right shoulder injury) Garbiñe Muguruza (final) Petra Martić (third round) Markéta Vondroušová (semifinals) Donna Vekić (second round) Zhang Shuai (withdrew) Anastasia Pavlyuchenkova (third round) Fiona Ferro (first round) Danielle Collins (quarterfinals) Nadia Podoroska (quarterfinals) Kristina Mladenovic (first round) Marie Bouzková (third round) ==Draw==