The knockout stage was played across 31 March/1/2 April with a single leg round of 16 matches consisting of the top six ranked teams from each pool and the teams ranked 9th and 10th in each pool of the
2022–23 European Rugby Champions Cup (
Clermont,
Lyon,
Racing 92 and
Sale Sharks denoted by * in the bracket). The Round of 16 followed a pre-determined format, while the quarter-finals and semi-finals always guaranteed home advantage to the higher ranked team. The last-16 were dominated by clubs from
Top 14 (eight) and the United Rugby Championship (six), with only two English clubs reaching the knockout stages - both eliminated in the first play-off round along with the only Irish team,
Connacht, while both South African clubs departed by the quarter-finals.
Treviso became the first Italian side to reach a European semi-final, as three URC teams from three different countries(Italy, Scotland and Wales) reached the final four along with French giant
Toulon. Round of 16 ---- ---- ---- ---- ---- ---- ----
Quarter-finals ---- ---- ----
Semi-finals The higher-ranked club gained home stadium advantage, however, in the event that a South African team had been the higher ranked side, the game would have been located in Europe. ----
Final == Leading scorers ==