Shuko Aoyama and Ena Shibahara defeated Nicole Melichar and Demi Schuurs in the final, 6–1, 6–4, to win the women's doubles tennis title at the 2021 Eastbourne International. It marked their fourth title together of the season, and their seventh consecutive win in a final match over two years. The victory earned Aoyama her 16th career WTA Tour doubles title and Shibahara's seventh.