The 2022 Grand Prix de Denain – Porte du Hainaut was the 63rd edition of the Grand Prix de Denain one-day road cycling race. It was held on 17 March 2022 as a category 1.Pro race on the 2022 UCI ProSeries calendar. It was also the second event of the 2022 French Road Cycling Cup. After the 2021 edition was postponed to September by COVID-19 precautions, the race returned to its usual spring timeslot.