The 2022 Indiana State Sycamores football team represented Indiana State University as a member of the Missouri Valley Football Conference (MVFC) during the 2022 NCAA Division I FCS football season. Led by fifth-year head coach Curt Mallory, the Sycamores compiled an overall record of 2–9 with a mark of 1–7 in conference play, placing tenth in the MVFC. Indiana State played home games at Memorial Stadium in Terre Haute, Indiana.