All teams used series-specified
Dunlop tyres and
Triumph 765cc
3-cylinder engines.
Team changes •
Forward Racing and
MV Agusta ended their partnership which started in . Forward Racing entered the 2023 season using motorcycles under their own brand.
Rider changes •
Dennis Foggia made his Moto2 debut with Italtrans Racing Team, replacing
Lorenzo Dalla Porta.
Rory Skinner replaced Beaubier at American Racing to make his full-time Moto2 debut, having appeared as a wildcard rider for the team in . •
Álex Escrig made his Moto2 debut with
Forward Team, replacing
Simone Corsi who became the rider coach for the team. Moto3 World Riders' Champion
Izan Guevara then moved up from Moto3 while remaining with GasGas Aspar Team, replacing Arenas. Binder made his Moto2 debut, having raced in
MotoGP in 2022. Tulovic, who is the 2022 Moto2 European Champion, returned to the Moto2 class, having last raced in . Tulovic also raced as a replacement rider in MotoE in 2022. •
Borja Gómez made his full-time debut with
Fantic Racing, He was not replaced. •
Álex Escrig competed during P1 of the Portuguese round, but withdrew after being declared unfit due to the effects of a right shoulder injury sustained during pre-season testing. He was replaced by
David Sanchis for the rest of the weekend, He was replaced by
Taiga Hada starting from the Italian round. He was again replaced by Ruiz for the Catalan round, He was again replaced for both races by Agius. •
Rory Skinner missed the German and Dutch rounds after suffering a fractured right foot during P3 of the Italian round. He was not replaced for the British round, and was replaced by Marcos Ramírez for the Austrian round. Ramírez raced for
Forward Team from the start of the season but parted ways with the team after the British round. He was replaced by
Alberto Surra starting from the Austrian round. Kelly parted ways with the team after the Austrian round. He was replaced by Ramírez as a full-time rider starting from the Catalan round. •
Taiga Hada missed the Austrian and Catalan rounds due to injury. He was replaced for both races by
Mattia Rato. •
Celestino Vietti missed the Japanese and Indonesian rounds due to a fractured pubic bone sustained in the Indian race. He was replaced by
Borja Gómez for the Japanese round, and by
Lorenzo Baldassarri for the Indonesian round. Gómez raced for
Fantic Racing from the start of the season as a regular rider and was Vietti's teammate but parted ways with the team after the Indian round. He was replaced by
Mattia Casadei as a full-time rider starting from the Japanese round. •
Alberto Surra missed the Malaysian round due to injury. He was replaced by Sean Dylan Kelly. Surra parted ways with the team after the Malaysian round. He was replaced by Kelly as a full-time rider starting from the Qatar round. == Regulation changes ==