Defending champion
Francesco Bagnaia won the inaugural sprint race in
Portugal, ahead of
Jorge Martín and
Marc Márquez, and repeated the win in the main race. At the second round in
Argentina,
KTM rider
Brad Binder took the sprint win, while
Marco Bezzecchi took his maiden premier class victory in a wet race. At the
Grand Prix of the Americas, Bagnaia took his second sprint victory.
Álex Rins stood atop the main race podium ahead of
Luca Marini and
Fabio Quartararo, marking the
LCR Honda team's first win since
Argentina 2018. Starting the European leg of the season in
Spain, Brad Binder took the sprint victory head of Francesco Bagnaia, while Bagnaia won the main race ahead of Binder. Both racing sessions were affected by
red flags, and KTM rider
Jack Miller closed out both podiums. The
French round marked the 1000th motorcycle Grand Prix since the series began in
1949. In the sprint, Jorge Martín took his first victory of the season, while Bezzecchi emerged as winner of the main race, followed by Martín and his teammate
Johann Zarco. At
Mugello, Bagnaia took his second weekend sweep of the season in front of the home crowd, winning both the sprint and main race. In
Germany, Jorge Martín took his first weekend sweep, winning both the sprint and main race after several close duels with Bagnaia. At the
Assen TT, Bezzecchi took pole position and victory in the sprint, before relinquishing the main race win to Bagnaia, finishing second. Heading into the summer break, Bagnaia led the championship with 194 points ahead of Martín on 159 and Bezzecchi on 158. Returning to action in
Britain, Marco Bezzecchi took his second consecutive pole position, but dropped the sprint win to
Álex Márquez, while Francesco Bagnaia failed to score points.
Aleix Espargaró took his first win of the season in the main race ahead of Bagnaia, while Bezzecchi crashed out. In
Austria, Bagnaia took his third weekend sweep of the season, finishing the main race in dominant fashion 5.1 seconds ahead of Brad Binder, with Bezzecchi taking third. With this result, Bagnaia held a 90-point lead over Jorge Martín at the midpoint of the season. In
Catalunya,
Aprilia's Aleix Espargaró swept his home Grand Prix weekend with a sprint win ahead of Bagnaia and a main race win ahead of teammate
Maverick Viñales and Jorge Martín. The main race was a disaster for
Ducati, who saw five riders crash in a single first-lap incident (Álex Márquez,
Enea Bastianini, Marco Bezzecchi,
Fabio Di Giannantonio and Johann Zarco) followed a few corners later by a crash for championship leader Francesco Bagnaia. His legs were run over by Brad Binder's KTM, a resulting minor injury ruled him out of restarting the race and would have further implications for the championship. At the final race of the European leg in
Misano, Martín completed a perfect weekend, taking pole position and victory in the sprint and main race, both times ahead of Bezzecchi and Bagnaia. At the inaugural
Indian Grand Prix, Jorge Martín won a rain-delayed sprint followed by Francesco Bagnaia and Marc Márquez. In the main race, Bagnaia crashed out after being involved in a duel with Martín, and Marco Bezzecchi took his third and final victory of the season, over 9 seconds ahead of Martín and Fabio Quartararo. With this result, Martín had reduce the championship gap to 13 points with seven races remaining. At the
Japanese round, Jorge Martín again had a perfect weekend, taking pole position and winning the sprint and main race. The main race was
red-flagged due to adverse weather conditions on lap 13 of 24. A restart was abandoned by race direction after the race was again red-flagged during the warm-up lap of the restarted race. Per regulations, full points were awarded since at least 50% of the original race distance were completed. In
Indonesia, Jorge Martín won his third consecutive sprint, ahead of Luca Marini and Marco Bezzecchi, securing
Ducati its fourth straight Constructors' Championship. With his victory in the sprint, Martín took over the lead of the standings for the first time in the season by 7 points. In the main race, Francesco Bagnaia quickly returned to the top of the standings, after winning from 13th position on the grid and Martín crashing out. The race marked the 500th Grand Prix victory for tyre marque
Michelin, whose first victory was in
1973 with
Jack Findlay. On
Phillip Island, heavy wind conditions caused a weekend schedule change, with the main race taking place on Saturday and the sprint on Sunday, weather permitting. In the main race, Johann Zarco took his maiden win in MotoGP, ahead of Bagnaia and Fabio Di Giannantonio. The sprint was cancelled due to inclement weather. At the
Thai round, Jorge Martín had his third perfect weekend of the year, with pole position and sprint and main race wins. In
Malaysia, Álex Márquez won the sprint ahead of Martín and Bagnaia, while Enea Bastianini took his first win of the season ahead of Márquez and Bagnaia. At the penultimate round in
Qatar, Luca Marini secured his second career pole position with an all-time lap record at the track. Jorge Martín took the win at the sprint race, while Francesco Bagnaia only managed 5th place. In the main race, Fabio Di Giannantonio took his maiden MotoGP win ahead of Bagnaia and Marini, while Martín struggled to a 10th-place finish. The final round at
Valencia saw Martín win his ninth sprint race of the season, cutting the championship gap to 14 points for the finale race. Martin crashed out of the main race while attempting to recover from an early mistake, while Bagnaia took the race victory, sealing his second consecutive MotoGP world title. == Teams and riders ==