The following are the seeded players. Seedings are based on ATP rankings as of April 24, 2023. Rankings and points before are as of April 24, 2023. Because the men's tournament is being expanded to two weeks this year, players are defending points from the
2022 Madrid Open, as well as tournaments that took place during the week of April 25, 2022 (
Estoril and
Munich). Points from the 2022 Madrid Open are listed first in the "Points defending" column. }
Daniil Medvedev † The player did not qualify for the main draw in 2022, but is defending points from
Estoril,
Munich, or
Mauthausen (ATP Challenger). ‡ The player did not qualify for the main draw in 2022. Points for his 19th best result will be deducted instead. § The player entered an
ATP Challenger Tour event in the second week of the Madrid tournament and points from that second tournament replaced his 19th (or 18th) best result.
Withdrawn players The following players would have been seeded, but withdrew before the tournament began. == Other entry information ==