Denis Shapovalov defeated Aleksandar Kovacevic in the final, 6–4, 6–2 to win the singles tennis title at the 2025 Los Cabos Open. He did not lose a set en route to his fourth career ATP Tour title, and first outside of indoor hardcourts. Shapovalov and Kovacevic were the first pair of players with one-handed backhands to contest an ATP Tour final since Stefanos Tsitsipas and Dominic Thiem at the 2019 ATP Finals.