Louisville, Kentucky In its Louisville location, 21c renovated five 19th-century warehouse buildings listed on the
National Register of Historic Places to house the museum, hotel, and restaurant. It is located within the city's arts and theater district along "Museum Row", which is home to the
Louisville Slugger Museum, the
Muhammad Ali Center, the
Frazier History Museum, the
Kentucky Museum of Art and Craft, and the
Kentucky Science Center. This location has a restaurant called Proof on Main, which was named one of the "Best New Restaurants of 2006" by
Esquire magazine. The menu features ingredients from local farms and food purveyors, as well as 50 types of
bourbon. Located outside the establishment stands "The Statue of David", a double-size, golden replica of
Michelangelo's David, created by Turkish artist
Serkan Özkaya. Originally a project for the Istanbul Biennial art exhibition, the statue collapsed under its weight. Özkaya salvaged and restored the statue and created two more casts, one of which was acquired by 21c Museum Hotels.
Deborah Berke & Partners Architects designed the facility, for which they won the
American Institute of Architects Kentucky Honor Award in 2011, the AIA NYS Excellence for Historic Preservation/Adaptive Reuse in 2007, and the Best of Year Award for Hospitality Design,
Interior Design Magazine, in 2006. The hotel was also inducted into
Historic Hotels of America, the official program of the National Trust for Historic Preservation.
Cincinnati, Ohio In its Cincinnati location, 21c undertook the complete renovation of the historic
Hotel Metropole, a building previously used for housing low-income residents. It cost $48 million to renovate the hotel. In 2025, the hotel was released by 21c.
Bentonville, Arkansas The third location opened in Bentonville in 2013. The hotel is located on land that was once a cornfield outside the urban center of Bentonville. The Bentonville location was named one of the top 15 hotels in the US by the
Travel + Leisure Magazine in 2017.
Durham, North Carolina In March 2015, 21c opened its fourth hotel in
Durham, North Carolina. In 2013, the company bought the historic
Hill Building for $5.25 million. With an investment of $48 million, the
Hill Building was renovated and converted into a hotel with 125 rooms. The hotel is centrally located in Downtown Durham and is a short walk from the Durham Bulls Stadium, the DPAC, and the Carolina Theater.
Lexington, Kentucky In February 2016, the Lexington hotel opened in the
Fayette National Bank Building.
Chicago, Illinois In February 2020, 21c opened a hotel in
Chicago, Illinois, renovating The James Hotel in Chicago's
River North Gallery District with 297 rooms and over 10,000 square feet of exhibition and meeting space. In 2025, the hotel was released by 21c.
St. Louis, Missouri In August 2023, the group opened their 173-room boutique hotel and art museum located in the Downtown West district of St. Louis.
Oklahoma City, Oklahoma In June 2016, 21c opened a hotel in
Oklahoma City, Oklahoma in the Fred Jones Assembly Plant. The plant was built in 1915 and was known for being where the
Ford Model T was assembled. In 2023, the location was released by 21c and became the Hyatt's Fordson.
Nashville, Tennessee In May 2017, the Nashville hotel opened in the historic Gray & Dudley building in downtown. In 2023 the location was released by 21c and became The Bankers Alley Hotel Nashville, Tapestry Collection by Hilton.
Kansas City, Missouri In July 2018, the group opened their 120 suite and gallery hotel in
Kansas City, Missouri, inside the historic
Savoy Hotel and Grill. In 2025 the location was released by 21c and became The Hotel Savoy, Tapestry Collection by Hilton.
Further developments An additional property location in
Pittsburgh is in active development in 2024. The future of another planned location in
Des Moines, Iowa is unclear now that "The Fifth" project, of which it was due to be a part, has stalled. The company had been looking to open a hotel in
Indianapolis in the
old city hall, with construction scheduled to begin in 2017; however, these plans were scrapped at the end of March 2017 due to problems with financing. ==Restaurants==