Under the 2023 districting plan adopted by the
National Electoral Institute (INE), which is to be used for the
2024,
2027 and
2030 federal elections, the 21st district is located in the state's eastern panhandle and covers 174
electoral precincts () across 12 of its
125 municipalities: •
Amecameca,
Atlautla,
Ayapango,
Cocotitlán,
Ecatzingo,
Juchitepec,
Ozumba,
Temamatla,
Tenango del Aire,
Tepetlixpa,
Tlalmanalco and the eastern portion of
Ixtapaluca. The head town (), where results from individual polling stations are gathered together and tallied, is the city of
Amecameca de Juárez. In the 2020 Census, the district reported a total population of 410,835. ==Previous districting schemes==