2C-T-2

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists 2C-T-2's dose as 12 to 25mg orally and its duration as 6 to 8hours. Its onset is within 1hour and peak effects occur after 1 to 2hours. The effects of 2C-T-2 have been described. Shulgin rated it as one of the "magical half-dozen" most important psychedelic phenethylamines, along with mescaline, 2C-B, 2C-T-7, and others. ==Toxicity==

A potential risk of neurotoxicity from 2C-T-2 use (and 2C chemical series in general) has been shown in serotonergic and dopaminergic neurons, however the assay used concentrations unlikely to translate to recreational use of the compound (>50 μM). This has also been shown to be magnified in serotonergic-containing cells with combined use of 2C series drugs with alcohol, MDMA, and methamphetamine. Severe 'intoxication' on 2C series drugs has been observed as behavior that includes intense hallucinations, agitation, aggression, violence, dysphoria, hypertension, tachycardia, seizures, and hyperthermia. == Interactions ==

2C-T-2 is metabolized by the monoamine oxidase (MAO) enzymes MAO-A and MAO-B. Monoamine oxidase inhibitors (MAOIs) such as phenelzine, tranylcypromine, moclobemide, and selegiline may potentiate the effects of 2C-T-2. This may result in overdose and serious toxicity. ==Pharmacology==

Pharmacodynamics 2C-T-2 acts as a serotonin 5-HT2 receptor agonist, including of the serotonin 5-HT2A and 5-HT2C receptors. 2C-T-2 has also shown to be a partial agonist of adrenergic receptors. ==Chemistry==

Synthesis The chemical synthesis of 2C-T-2 has been described. Analogues Analogues of 2C-T-2 include 2C-T (2C-T-1), 2C-T-4, 2C-T-7, Aleph-2, and 25T2-NBOMe, among others. ==History==

2C-T-2 was first synthesized by Alexander Shulgin in 1981. He discovered its psychedelic effects that same year. The drug was first described in the scientific literature by Myron Stolaroff in 1990. Subsequently, it was described in greater detail in a 1991 publication by Shulgin and colleagues and in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). Following this, 2C-T-2 emerged as a novel designer drug in the 1990s. ==Society and culture==

Legal status Argentina 2C-T-2 is a controlled substance in Argentina along with 2C-B and 2C-I. Australia 2C-T-2 is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015). A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities. China As of October 2015 2C-T-2 is a controlled substance in China. Finland 2C-T-2 is classified as a narcotic drug in Finland. Netherlands The Netherlands became the first country in the world to ban 2C-T-2, and classify it as a hard drug, by law. In April, 1999, 2C-T-2 became a list I drug of the Opium Law. Sweden Schedule I in Sweden. 2C-T-2 was first classified as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of April 1, 1999, under SFS 1999:58 that made it illegal to sell or possess. The Riksdag added 2C-T-2 to Narcotic Drugs Punishments Act under Swedish schedule I ("substances, plant materials and fungi which normally do not have medical use") as of March 16, 2004, published by Medical Products Agency (MPA) in regulation LVFS 2004:3 listed as 2C-T-2, 2,5-dimetoxi-4-etyltiofenetylamin. United Kingdom 2C-T-2 and all other compounds featured in PiHKAL are illegal drugs in the United Kingdom. United States 2C-T-2 is specifically listed as a schedule I substance under SEC. 1152 of S.3187: Food and Drug Administration Safety and Innovation Act of 2012. == See also ==